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Review
. 2000 Apr;117(4):1162-72.
doi: 10.1378/chest.117.4.1162.

Anti-inflammatory cytokines

S M Opal  1 , V A DePalo
Affiliations
Review

Anti-inflammatory cytokines

S M Opal et al. Chest. 2000 Apr.

Abstract

The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the proinflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response. Their physiologic role in inflammation and pathologic role in systemic inflammatory states are increasingly recognized. Major anti-inflammatory cytokines include interleukin (IL)-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13. Specific cytokine receptors for IL-1, tumor necrosis factor-alpha, and IL-18 also function as proinflammatory cytokine inhibitors. The nature of anti-inflammatory cytokines and soluble cytokine receptors is the focus of this review. The current and future therapeutic uses of these anti-inflammatory cytokines are also reviewed.

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Comment in

  • Can we make sense out of cytokines?
    Fein AM, Abraham EM. Fein AM, et al. Chest. 2000 Apr;117(4):932-4. doi: 10.1378/chest.117.4.932. Chest. 2000. PMID: 10767220 Review. No abstract available.

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