doi: 10.1016/s0014-5793(00)01337-5.
In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats
Affiliations
- PMID: 10745090
- DOI: 10.1016/s0014-5793(00)01337-5
Item in Clipboard
In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats
FEBS Lett.
.
Free article
Abstract
To clarify the effect of hepatocyte growth factor (HGF) on proliferation of hepatic oval cells, we transferred HGF gene into liver of the Solt-Farber rat model. Male Fisher 344 rats were infected with a recombinant adenovirus carrying the cDNA for HGF (pAxCAHGF) from tail vein. HGF mRNA showed its peak at 4 days, and diminished thereafter. The total and proliferating cell nuclear antigen-positive hepatic oval cells were significantly elevated in HGF-transferred rats, in which stem cell factor and c-kit mRNA increased at each time point. Our results suggest that in vivo transfer of the HGF gene into liver accelerates proliferation of hepatic oval cells in the Solt-Farber model in rats.
Similar articles
-
Hepatocyte growth factor as well as vascular endothelial growth factor gene induction effectively promotes liver regeneration after hepatectomy in Solt-Farber rats.Hepatogastroenterology. 2005 Sep-Oct;52(65):1393-7. Hepatogastroenterology. 2005. PMID: 16201081
-
Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat.Am J Pathol. 1993 Jun;142(6):1823-30. Am J Pathol. 1993. PMID: 8506951 Free PMC article.
-
Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats.J Gastroenterol Hepatol. 2005 Nov;20(11):1753-61. doi: 10.1111/j.1440-1746.2005.03922.x. J Gastroenterol Hepatol. 2005. PMID: 16246197
-
Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.Biochem Biophys Res Commun. 2005 Sep 30;335(3):723-9. doi: 10.1016/j.bbrc.2005.07.127. Biochem Biophys Res Commun. 2005. PMID: 16087157
-
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.Carcinogenesis. 1996 Jan;17(1):19-24. doi: 10.1093/carcin/17.1.19. Carcinogenesis. 1996. PMID: 8565131
Cited by
-
Mouse A6-positive hepatic oval cells derived from embryonic stem cells.J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):1-9. doi: 10.1007/s11596-014-1223-2. Epub 2014 Feb 6. J Huazhong Univ Sci Technolog Med Sci. 2014. PMID: 24496671
-
TWEAK induces liver progenitor cell proliferation.J Clin Invest. 2005 Sep;115(9):2330-40. doi: 10.1172/JCI23486. Epub 2005 Aug 18. J Clin Invest. 2005. PMID: 16110324 Free PMC article.
-
Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation.Gut. 2002 Apr;50(4):558-62. doi: 10.1136/gut.50.4.558. Gut. 2002. PMID: 11889079 Free PMC article.
-
Effect of Puerarin Regulated mTOR Signaling Pathway in Experimental Liver Injury.Front Pharmacol. 2018 Oct 23;9:1165. doi: 10.3389/fphar.2018.01165. eCollection 2018. Front Pharmacol. 2018. PMID: 30405406 Free PMC article.
-
VEGF(165) expressing bone marrow mesenchymal stem cells differentiate into hepatocytes under HGF and EGF induction in vitro.Cytotechnology. 2012 Dec;64(6):635-47. doi: 10.1007/s10616-012-9439-0. Epub 2012 Apr 4. Cytotechnology. 2012. PMID: 22476563 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
