Review
doi: 10.1016/s1367-5931(99)00070-8.
Zinc-dependent protein folding
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- PMID: 10742185
- DOI: 10.1016/s1367-5931(99)00070-8
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Review
Zinc-dependent protein folding
Curr Opin Chem Biol.
2000 Apr.
Abstract
Studies of classic zinc-finger peptides over the past 15 years have offered insights into the coupled processes of metal binding and protein folding. Within the past two years, this insight has been used to increase our understanding of the importance of first and second shell contributions (i.e. contributions from direct and indirect metal ligands) to metal binding and protein-folding stability, and led to advances in de novo protein design and protein redesign.
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