A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
- PMID: 10742146
- DOI: 10.1038/74656
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
Abstract
The amyloid beta-protein precursor gives rise to the amyloid beta-protein, the principal constituent of senile plaques and a cytotoxic fragment involved in the pathogenesis of Alzheimer disease. Here we show that amyloid beta-protein precursor was proteolytically cleaved by caspases in the C terminus to generate a second unrelated peptide, called C31. The resultant C31 peptide was a potent inducer of apoptosis. Both caspase-cleaved amyloid beta-protein precursor and activated caspase-9 were present in brains of Alzheimer disease patients but not in control brains. These findings indicate the possibility that caspase cleavage of amyloid beta-protein precursor with the generation of C31 may be involved in the neuronal death associated with Alzheimer disease.
Comment in
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Caspase cleavage of APP results in a cytotoxic proteolytic peptide.Nat Med. 2000 Apr;6(4):385-6. doi: 10.1038/74644. Nat Med. 2000. PMID: 10742143 No abstract available.
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