doi: 10.1110/ps.9.1.194.
Kinetic evidence of an on-pathway intermediate in the folding of lysozyme
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- PMID: 10739262
- PMCID: PMC2144436
- DOI: 10.1110/ps.9.1.194
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Kinetic evidence of an on-pathway intermediate in the folding of lysozyme
Protein Sci.
2000 Jan.
Abstract
By means of a kinetic test, it was demonstrated that one of the folding intermediates (Ialpha) of hen lysozyme with alpha-domain folded and beta-domain unfolded is on the folding pathway under the classical definition. Ialpha folds to the native (N) state directly (unfolded (U) <==> Ialpha <==> N) without having to unfold to U and then refold to N through alternative folding pathways as in Ialpha <==> U <==> N.
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