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. 2000 Mar;94(3):192-9.
doi: 10.1006/clim.2000.4835.

Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice

M Jacobs  1 , N Brown, N Allie, B Ryffel
Affiliations

Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice

M Jacobs et al. Clin Immunol. 2000 Mar.

Abstract

Neutralization of TNF or disruption of TNF-R1 leads to fatal Mycobacterium bovis BCG infection. Here we used TNF-LT-alpha-deficient mice to test whether a complete disruption of TNF and LT-alpha reduces further host resistance to BCG infection. The bacterial burden especially in the lungs of TNF-LT-alpha-deficient mice was significantly increased and the mice succumbed to infection between 8 and 10 weeks. In the absence of TNF-LT-alpha the granulomatous response was severely impaired and delayed. The cells in the granulomas of TNF-LT-alpha-deficient mice expressed low levels of MHC class II and ICAM-1. They contained a few T cells and F4/80-positive macrophages expressing little iNOS and acid phosphatase activity. By contrast, the lethal action of endotoxin was dramatically reduced in BCG-infected TNF-LT-alpha-deficient mice. In summary, in the absence of TNF-LT-alpha the recruitment and activation of mononuclear cells in response to BCG infection were significantly delayed and reduced resulting in immature granulomas allowing uncontrolled fatal infection.

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