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. 2000 Feb 25;287(5457):1485-9.
doi: 10.1126/science.287.5457.1485.

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

F Chen  1 , B M Hersh, B Conradt, Z Zhou, D Riemer, Y Gruenbaum, H R Horvitz
Affiliations

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

F Chen et al. Science. .

Abstract

The Caenorhabditis elegans Bcl-2-like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1-like cell-death activator CED-4. Endogenous CED-9 and CED-4 proteins localized to mitochondria in wild-type embryos, in which most cells survive. By contrast, in embryos in which cells had been induced to die, CED-4 assumed a perinuclear localization. CED-4 translocation induced by the cell-death activator EGL-1 was blocked by a gain-of-function mutation in ced-9 but was not dependent on ced-3 function, suggesting that CED-4 translocation precedes caspase activation and the execution phase of programmed cell death. Thus, a change in the subcellular localization of CED-4 may drive programmed cell death.

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