doi: 10.1016/s1286-4579(99)80059-8.
Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene
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- PMID: 10611736
- DOI: 10.1016/s1286-4579(99)80059-8
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Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene
Microbes Infect.
1999 Jul.
Free article
Abstract
In order to determine the ability of herpes simplex virus type 2 (HSV-2) to suppress apoptosis, we examined the effect of HSV-2 infection on apoptosis induced in HEp-2 cells by treatment with 1 M sorbitol. Although a wild-type strain of HSV-2 induced apoptosis in a significant fraction of the infected cells, HSV-2 could suppress sorbitol-induced apoptosis in a manner similar to that of herpes simplex virus type 1 (HSV-1), indicating that HSV-2, like HSV-1, has an antiapoptosis gene. Characterization of the cells infected with a US3-deletion mutant of HSV-2 revealed the necessity of a US3 gene in the antiapoptotic activity of this virus.
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