Review
doi: 10.1016/s0959-440x(99)00036-6.
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
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- PMID: 10607676
- DOI: 10.1016/s0959-440x(99)00036-6
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Review
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
Curr Opin Struct Biol.
1999 Dec.
Abstract
Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxygen activation that involve iron-mediated electron transfer.
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