Comparative Study
doi: 10.1016/s0014-5793(99)01662-2.
LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
Affiliations
- PMID: 10606755
- DOI: 10.1016/s0014-5793(99)01662-2
Item in Clipboard
Comparative Study
LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
FEBS Lett.
.
Free article
Abstract
Recent findings indicate that cytokine signaling can be modulated by other mediators of simultaneously activated signal transduction pathways. In this study we show that LPS and TNFalpha are potent inhibitors of IL-6-mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. Accordingly, LPS and TNFalpha were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFalpha.
Similar articles
-
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.J Immunol. 2003 Mar 15;170(6):3263-72. doi: 10.4049/jimmunol.170.6.3263. J Immunol. 2003. PMID: 12626585
-
Expression of STAT3 and SOCS3 in pancreatic acinar cells.J Surg Res. 2005 Jul 1;127(1):14-20. doi: 10.1016/j.jss.2005.03.019. J Surg Res. 2005. PMID: 15893771
-
TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.J Immunol. 2003 Jul 1;171(1):257-66. doi: 10.4049/jimmunol.171.1.257. J Immunol. 2003. PMID: 12817006
-
Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.J Immunol. 2000 Nov 1;165(9):5227-37. doi: 10.4049/jimmunol.165.9.5227. J Immunol. 2000. PMID: 11046056
-
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.Biol Chem. 2001 Oct;382(10):1447-53. doi: 10.1515/BC.2001.178. Biol Chem. 2001. PMID: 11727828
Cited by
-
Role of interleukin-6 in cancer progression and therapeutic resistance.Tumour Biol. 2016 Sep;37(9):11553-11572. doi: 10.1007/s13277-016-5098-7. Epub 2016 Jun 3. Tumour Biol. 2016. PMID: 27260630 Review.
-
Free fatty acid palmitate impairs the vitality and function of cultured human bladder smooth muscle cells.PLoS One. 2012;7(7):e41026. doi: 10.1371/journal.pone.0041026. Epub 2012 Jul 13. PLoS One. 2012. PMID: 22808290 Free PMC article.
-
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.J Clin Invest. 2006 Jun;116(6):1571-81. doi: 10.1172/JCI25660. Epub 2006 May 18. J Clin Invest. 2006. PMID: 16710471 Free PMC article.
-
The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals.J Immunol. 2009 Jun 15;182(12):7558-68. doi: 10.4049/jimmunol.0803666. J Immunol. 2009. PMID: 19494279 Free PMC article.
-
Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation.Int J Mol Sci. 2021 Aug 12;22(16):8686. doi: 10.3390/ijms22168686. Int J Mol Sci. 2021. PMID: 34445392 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
