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. 1999 Nov 12;286(5443):1353-7.
doi: 10.1126/science.286.5443.1353.

Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells

Z Zhang  1 , T Schuler, M Zupancic, S Wietgrefe, K A Staskus, K A Reimann, T A Reinhart, M Rogan, W Cavert, C J Miller, R S Veazey, D Notermans, S Little, S A Danner, D D Richman, D Havlir, J Wong, H L Jordan, T W Schacker, P Racz, K Tenner-Racz, N L Letvin, S Wolinsky, A T Haase
Affiliations

Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells

Z Zhang et al. Science. .

Erratum in

  • Science 1999 Dec 17;286(5448):2273

Abstract

In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.

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