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. 1999 Dec;180(6):1939-49.
doi: 10.1086/315124.

A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species

T Hamouda  1 , M M Hayes, Z Cao, R Tonda, K Johnson, D C Wright, J Brisker, J R Baker Jr
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A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species

T Hamouda et al. J Infect Dis. 1999 Dec.

Abstract

Two nontoxic, antimicrobial nanoemulsions, BCTP and BCTP 401, have been developed. These emulsions are composed of detergents and oils in 80% water. BCTP diluted up to 1:1000 inactivated>90% of Bacillus anthracis spores in 4 h and was also sporicidal against three other Bacillus species. This sporicidal activity is due to disruption of the spore coat after initiation of germination without complete outgrowth. BCTP 401 diluted 1:1000 had greater activity than BCTP against Bacillus spores and had an onset of action of <30 min. Mixing BCTP or BCTP 401 with Bacillus cereus prior to subcutaneous injection in mice reduced the resulting skin lesion by 99%. Wound irrigation with BCTP 1 h after spore inoculation yielded a 98% reduction in skin lesion size, and mortality was reduced 3-fold. These nanoemulsion formulas are stable, easily dispersed, nonirritant, and nontoxic compared with other available sporicidal agents.

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