Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonary disease
- PMID: 10556171
- DOI: 10.1164/ajrccm.160.supplement_1.14
Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonary disease
Abstract
The application of sputum induction and refined methods of sputum examination has provided the opportunity to examine cell and molecular markers of airway inflammation in asthma, COPD, and other airway diseases. The measurements are relatively noninvasive and can be applied safely, with care, even in more severe exacerbations of asthma and severe COPD. Induced sputum examination can be applied at random and repeatedly and gives results that are reproducible, valid, and responsive to changes in treatment. An eosinophilic bronchitis, defined as sputum eosinophilia, is typical of asthma but can also occur in patients with a chronic cough without asthma, and in some patients with COPD in whom the classic inflammatory response is neutrophilic without eosinophilia. When eosinophilia occurs in COPD, it has been considered to be the result of cigarette smoking but it may be due to other causes. The clinical importance of eosinophilic bronchitis is that it responds to treatment with corticosteroid. In contrast, there is increasing evidence that an absence of sputum eosinophilia is associated with steroid resistance. Hargreave FE, Leigh R. Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonary disease.
Similar articles
-
Eosinophilic airway disorders.Semin Respir Crit Care Med. 2006 Apr;27(2):128-33. doi: 10.1055/s-2006-939515. Semin Respir Crit Care Med. 2006. PMID: 16612763 Review.
-
Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma.Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):878-82. doi: 10.1164/ajrccm.162.3.9909064. Am J Respir Crit Care Med. 2000. PMID: 10988099
-
[Value of sputum analysis in the management of inflammatory airway diseases].Medicina (B Aires). 2012;72(4):332-8. Medicina (B Aires). 2012. PMID: 22892087 Review. Spanish.
-
Relationship between sputum eosinophilia and sinus disease in patients with eosinophilic bronchitis.Am J Rhinol Allergy. 2014 Sep-Oct;28(5):378-82. doi: 10.2500/ajra.2014.28.4084. Am J Rhinol Allergy. 2014. PMID: 25198022
-
Eosinophilic bronchitis: an important cause of prolonged cough.Ann Med. 2000 Oct;32(7):446-51. doi: 10.3109/07853890009002019. Ann Med. 2000. PMID: 11087164 Review.
Cited by
-
Sputum neutrophilia can mask eosinophilic bronchitis during exacerbations.Can Respir J. 2007 Jul-Aug;14(5):281-4. doi: 10.1155/2007/190618. Can Respir J. 2007. PMID: 17703243 Free PMC article.
-
Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study.Thorax. 2003 Feb;58(2):135-42. doi: 10.1136/thorax.58.2.135. Thorax. 2003. PMID: 12554896 Free PMC article.
-
Identification and validation of nebulized aerosol devices for sputum induction.Can Respir J. 2014 Mar-Apr;21(2):101-6. doi: 10.1155/2014/925305. Epub 2013 Nov 28. Can Respir J. 2014. PMID: 24288700 Free PMC article.
-
Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD.Respiration. 2009;78(3):256-62. doi: 10.1159/000221902. Epub 2009 May 27. Respiration. 2009. PMID: 19478474 Free PMC article.
-
Anti-IL5 therapy for asthma and beyond.World Allergy Organ J. 2014 Dec 4;7(1):32. doi: 10.1186/1939-4551-7-32. eCollection 2014. World Allergy Organ J. 2014. PMID: 25709744 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
