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. 1999 Oct 29;286(5441):952-4.
doi: 10.1126/science.286.5441.952.

TCR-Mediated internalization of peptide-MHC complexes acquired by T cells

J F Huang  1 , Y Yang, H Sepulveda, W Shi, I Hwang, P A Peterson, M R Jackson, J Sprent, Z Cai
Affiliations

TCR-Mediated internalization of peptide-MHC complexes acquired by T cells

J F Huang et al. Science. .

Abstract

Peptide-major histocompatibility complex protein complexes (pMHCs) on antigen-presenting cells (APCs) are central to T cell activation. Within minutes of peptide-specific T cells interacting with APCs, pMHCs on APCs formed clusters at the site of T cell contact. Thereafter, these clusters were acquired by T cells and internalized through T cell receptor-mediated endocytosis. During this process, T cells became sensitive to peptide-specific lysis by neighboring T cells (fratricide). This form of immunoregulation could explain the "exhaustion" of T cell responses that is induced by high viral loads and may serve to down-regulate immune responses.

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