Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Nov;73(11):9638-41.
doi: 10.1128/JVI.73.11.9638-9641.1999.

Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals

L A Cavacini  1 , J E Peterson, E Nappi, M Duval, R Goldstein, K Mayer, M R Posner
Affiliations

Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals

L A Cavacini et al. J Virol. 1999 Nov.

Abstract

Immunoglobulin G reactive with primary isolate virions was detected in 36% of serum samples from individuals infected with human immunodeficiency virus type 1. Of these individuals, serum samples from only 7% captured significant quantities of virus. Virion-specific antibody correlated with CD4 counts and, of more significance, primary isolate neutralization. Further dissection of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Relationship of serum antibody reactivity with virions and CD4 counts. A scatter plot of the correlation of virus captured by human plasma as described in Table 1 with CD4 counts is shown. For a concentration of <300 pg/ml, n = 56; for 300 to 500 pg/ml, n = 25; for >500 pg/ml, n = 6.
FIG. 2
FIG. 2
Association of virion-specific antibodies with virus neutralization. The correlation of virus captured by human plasma as described in Table 1 with primary isolate neutralization is shown. For a concentration of <300 pg/ml, n = 18; for 300 to 500 pg/ml, n = 24; for >500 pg/ml, n = 6.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arthur L O, Bess J W J, Sowder II R C, Benveniste R E, Mann D L, Cherman J-C, Henderson L E. Cellular proteins bound to immunodeficiency viruses: implication for pathogenesis and vaccines. Science. 1992;258:1935–1938. - PubMed
    1. Bastiani L, Laal S, Kim M, Zolla-Pazner S. Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions. J Virol. 1997;71:3444–3450. - PMC - PubMed
    1. Cavacini L A, Emes C, Power J, Gorny M, Zolla-Pazner S, Posner M R. Human monoclonal antibodies to the V3 loop of gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site. J Acquir Immun Defic Syndr. 1993;6:353–358. - PubMed
    1. Cavacini L A, Emes C L, Power J, Duval M, Posner M R. Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization. J Immunol. 1994;152:2538–2545. - PubMed
    1. Cavacini L A, Emes C L, Power J, Desharnais F, Duval M, Montefiori D, Posner M R. Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody. J Immunol. 1995;155:3638–3644. - PubMed

Publication types