doi: 10.1016/s1074-7613(00)80103-x.
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
Affiliations
- PMID: 10514006
- DOI: 10.1016/s1074-7613(00)80103-x
Item in Clipboard
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
Immunity.
1999 Sep.
Free article
Retraction in
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Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.Immunity. 2009 Apr 17;30(4):611. doi: 10.1016/j.immuni.2009.04.002. Immunity. 2009. PMID: 19382300 No abstract available.
Abstract
IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). The molecular basis of these different effects of IL-2 was studied by introducing wild-type and mutant forms of the IL-2 receptor beta (IL-2Rbeta) chain that lacked specific signaling capacities into receptor-deficient T cells by retroviral gene transfer. Activation of Stat5 by IL-2 was found to be involved in T cell proliferation and promoted Fas ligand (FasL) expression and AICD. T cell survival was dependent on a receptor region that activated Akt and the expression of Bcl-2. Thus, distinct IL-2Rbeta chain signaling modules regulate T cell fate by stimulating growth and survival or by promoting apoptosis.
Comment in
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Findings of scientific misconduct.NIH Guide Grants Contracts. 2009 Jan 30:NOT-OD-09-040. NIH Guide Grants Contracts. 2009. PMID: 19186376 Free PMC article. No abstract available.
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