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Clinical Trial
. 1999 Sep;87(3):1003-8.
doi: 10.1152/jappl.1999.87.3.1003.

Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study

C Bouchard  1 , P An, T Rice, J S Skinner, J H Wilmore, J Gagnon, L Pérusse, A S Leon, D C Rao
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Free article
Clinical Trial

Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study

C Bouchard et al. J Appl Physiol (1985). 1999 Sep.
Free article

Abstract

The aim of this study was to test the hypothesis that individual differences in the response of maximal O(2) uptake (VO(2max)) to a standardized training program are characterized by familial aggregation. A total of 481 sedentary adult Caucasians from 98 two-generation families was exercise trained for 20 wk and was tested for VO(2max) on a cycle ergometer twice before and twice after the training program. The mean increase in VO(2max) reached approximately 400 ml/min, but there was considerable heterogeneity in responsiveness, with some individuals experiencing little or no gain, whereas others gained >1.0 l/min. An ANOVA revealed that there was 2.5 times more variance between families than within families in the VO(2max) response variance. With the use of a model-fitting procedure, the most parsimonious models yielded a maximal heritability estimate of 47% for the VO(2max) response, which was adjusted for age and sex with a maternal transmission of 28% in one of the models. We conclude that the trainability of VO(2max) is highly familial and includes a significant genetic component.

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