Stat3 as an oncogene
- PMID: 10458605
- DOI: 10.1016/s0092-8674(00)81959-5
Stat3 as an oncogene
Erratum in
- Cell 1999 Oct 15;99(2):239
Abstract
STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis. We report that substitution of two cysteine residues within the C-terminal loop of the SH2 domain of Stat3 produces a molecule that dimerizes spontaneously, binds to DNA, and activates transcription. The Stat3-C molecule in immortalized fibroblasts causes cellular transformation scored by colony formation in soft agar and tumor formation in nude mice. Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus attention on the importance of constitutive Stat3 activation in human tumors.
Similar articles
-
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.J Biol Chem. 2000 Aug 11;275(32):24935-44. doi: 10.1074/jbc.M002383200. J Biol Chem. 2000. PMID: 10823829
-
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.J Biol Chem. 1996 May 31;271(22):12999-3007. doi: 10.1074/jbc.271.22.12999. J Biol Chem. 1996. PMID: 8662795
-
Stat3 activation is required for cellular transformation by v-src.Mol Cell Biol. 1998 May;18(5):2553-8. doi: 10.1128/MCB.18.5.2553. Mol Cell Biol. 1998. PMID: 9566875 Free PMC article.
-
The role of STATs in transcriptional control and their impact on cellular function.Oncogene. 2000 May 15;19(21):2468-73. doi: 10.1038/sj.onc.1203476. Oncogene. 2000. PMID: 10851045 Review.
-
STATs and gene regulation.Science. 1997 Sep 12;277(5332):1630-5. doi: 10.1126/science.277.5332.1630. Science. 1997. PMID: 9287210 Review.
Cited by
-
Hydrazinocurcumin Encapsuled nanoparticles "re-educate" tumor-associated macrophages and exhibit anti-tumor effects on breast cancer following STAT3 suppression.PLoS One. 2013 Jun 25;8(6):e65896. doi: 10.1371/journal.pone.0065896. Print 2013. PLoS One. 2013. PMID: 23825527 Free PMC article.
-
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.Oncotarget. 2012 Mar;3(3):236-60. doi: 10.18632/oncotarget.466. Oncotarget. 2012. PMID: 22470194 Free PMC article. Review.
-
STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance.Front Oncol. 2015 Jun 8;5:121. doi: 10.3389/fonc.2015.00121. eCollection 2015. Front Oncol. 2015. PMID: 26106584 Free PMC article. Review.
-
Cancer prevention with promising natural products: mechanisms of action and molecular targets.Anticancer Agents Med Chem. 2012 Dec;12(10):1159-84. doi: 10.2174/187152012803833035. Anticancer Agents Med Chem. 2012. PMID: 22583402 Free PMC article. Review.
-
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.Cell Death Dis. 2022 Nov 28;13(11):1007. doi: 10.1038/s41419-022-05456-7. Cell Death Dis. 2022. PMID: 36443287 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
