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. 1999 Sep;67(9):4935-8.
doi: 10.1128/IAI.67.9.4935-4938.1999.

Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination

K R Lottenbach  1 , C M Mink, S J Barenkamp, E L Anderson, S M Homan, D C Powers
Affiliations

Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination

K R Lottenbach et al. Infect Immun. 1999 Sep.

Abstract

Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups.

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Figures

FIG. 1
FIG. 1
Ratio of postvaccination geometric mean IgG1/IgG2 antibody responses in relation to age after immunization with licensed 23-valent Pn PV (A) or protein-conjugated Pn PV CV1 or CV2 (B).
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