Review
doi: 10.1139/o99-001.
The Cdx-1 and Cdx-2 homeobox genes in the intestine
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- PMID: 10392709
- DOI: 10.1139/o99-001
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Review
The Cdx-1 and Cdx-2 homeobox genes in the intestine
Biochem Cell Biol.
1998.
Abstract
The past years have witnessed an increasing number of reports relative to homeobox genes in endoderm-derived tissues. In this review, we focus on the caudal-related Cdx-1 and Cdx-2 homeobox genes to give an overview of the in vivo, in vitro, and ex vivo approaches that emphasize their primary role in intestinal development and in the control of intestinal cell proliferation, differentiation, and identity. The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed.
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