Review
doi: 10.1016/s0962-8924(99)01586-x.
First the CDKs, now the DDKs
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- PMID: 10370238
- DOI: 10.1016/s0962-8924(99)01586-x
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Review
First the CDKs, now the DDKs
Trends Cell Biol.
1999 Jul.
Abstract
In budding yeast, Dbf4p and Cdc7p control initiation of DNA synthesis. They form a protein kinase - Cdc7p being the catalytic subunit and Dbf4p a cyclin-like molecule that activates the kinase in late G1 phase. Dbf4p also targets Cdc7p to origins of replication, where probable substrates include certain Mcm proteins. Recent studies have identified Dbf4p- and Cdc7p-related proteins in fission yeast and metazoans. These homologues also phosphorylate Mcm proteins and could have a similar function to that of Dbf4p-Cdc7p in budding yeast. Thus, it seems likely that, like the cyclin-dependent kinases (CDKs), the Dbf4p-Cdc7p activity is conserved in all eukaryotes.
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