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Comment
. 1999 Jun 4;284(5420):1664-6.
doi: 10.1126/science.284.5420.1664.

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

M D Tortorella  1 , T C Burn, M A Pratta, I Abbaszade, J M Hollis, R Liu, S A Rosenfeld, R A Copeland, C P Decicco, R Wynn, A Rockwell, F Yang, J L Duke, K Solomon, H George, R Bruckner, H Nagase, Y Itoh, D M Ellis, H Ross, B H Wiswall, K Murphy, M C Hillman Jr, G F Hollis, R C Newton, R L Magolda, J M Trzaskos, E C Arner
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Comment

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

M D Tortorella et al. Science. .

Abstract

We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.

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