Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas
- PMID: 10353745
Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas
Abstract
Macrophages are key participants in angiogenesis. In this study on human brain tumors, we first investigated whether macrophage infiltration is associated with angiogenesis and malignant histological appearance. Immunostaining of macrophages and small vessels in resected glioma specimens indicated that numbers of infiltrating macrophages and small vessel density were higher in glioblastomas than in astrocytomas or anaplastic astrocytomas. Macrophage infiltration was closely correlated with vascular density in human gliomas. Heme oxygenase-1 (HO-1), which is the rate-limiting enzyme in heme catabolism, was also associated with activated macrophages. Expression of mRNA encoding HO-1 was correlated with macrophage infiltration and vascular density in human glioma samples. Infiltrating macrophages were positively stained with anti-HO-1 antibody by immunohistochemical analysis, and in situ hybridization for HO-1 indicated that HO-1 was expressed in infiltrating macrophages in gliomas. HO-1 gene may be a useful marker for macrophage infiltration as well as neovascularization in human gliomas.
Similar articles
-
Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells.J Neurosurg. 2001 Jun;94(6):961-71. doi: 10.3171/jns.2001.94.6.0961. J Neurosurg. 2001. PMID: 11409526
-
Heme oxygenase (HO)-1 expressing macrophages/microglial cells accumulate during oligodendroglioma progression.Brain Res. 2000 Nov 3;882(1-2):1-8. doi: 10.1016/s0006-8993(00)02594-4. Brain Res. 2000. PMID: 11056178
-
Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas.Jpn J Cancer Res. 2000 Sep;91(9):906-10. doi: 10.1111/j.1349-7006.2000.tb01033.x. Jpn J Cancer Res. 2000. PMID: 11011118 Free PMC article.
-
Histologic measures of angiogenesis in human primary brain tumors.Cancer Treat Res. 2004;117:79-95. doi: 10.1007/978-1-4419-8871-3_4. Cancer Treat Res. 2004. PMID: 15015553 Review.
-
Glioma malignancy and its biological and histological correlates.J Neurosurg Sci. 1990 Jul-Dec;34(3-4):163-5. J Neurosurg Sci. 1990. PMID: 1711575 Review.
Cited by
-
Osteopontin increases heme oxygenase-1 expression and subsequently induces cell migration and invasion in glioma cells.Neuro Oncol. 2012 Nov;14(11):1367-78. doi: 10.1093/neuonc/nos262. Epub 2012 Oct 16. Neuro Oncol. 2012. PMID: 23074199 Free PMC article.
-
Evaluating the SERCA2 and VEGF mRNAs as Potential Molecular Biomarkers of the Onset and Progression in Huntington's Disease.PLoS One. 2015 Apr 27;10(4):e0125259. doi: 10.1371/journal.pone.0125259. eCollection 2015. PLoS One. 2015. PMID: 25915065 Free PMC article.
-
Clinical Significance of Heme Oxygenase 1 in Tumor Progression.Antioxidants (Basel). 2021 May 17;10(5):789. doi: 10.3390/antiox10050789. Antioxidants (Basel). 2021. PMID: 34067625 Free PMC article. Review.
-
Tumor-associated macrophages in glioblastoma multiforme-a suitable target for somatostatin receptor-based imaging and therapy?PLoS One. 2015 Mar 25;10(3):e0122269. doi: 10.1371/journal.pone.0122269. eCollection 2015. PLoS One. 2015. PMID: 25807228 Free PMC article.
-
Tumor-Associated Macrophages: Reasons to Be Cheerful, Reasons to Be Fearful.Exp Suppl. 2022;113:107-140. doi: 10.1007/978-3-030-91311-3_4. Exp Suppl. 2022. PMID: 35165862
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical