doi: 10.1212/wnl.52.8.1687.
Correlation between rates of brain atrophy and cognitive decline in AD
Affiliations
- PMID: 10331700
- DOI: 10.1212/wnl.52.8.1687
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Correlation between rates of brain atrophy and cognitive decline in AD
Neurology.
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Abstract
Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.
Comment in
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The search for diagnostic and progression markers in AD: so near but still too far?Neurology. 1999 May 12;52(8):1533-4. doi: 10.1212/wnl.52.8.1533. Neurology. 1999. PMID: 10331672 No abstract available.
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