Review
doi: 10.1046/j.1365-2958.1999.01287.x.
Termination of DNA replication of bacterial and plasmid chromosomes
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- PMID: 10209736
- DOI: 10.1046/j.1365-2958.1999.01287.x
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Review
Termination of DNA replication of bacterial and plasmid chromosomes
Mol Microbiol.
1999 Mar.
Free article
Abstract
Sequence-specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis-acting ter site and a trans-acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein-DNA complex that arrests replication forks in a polar fashion by antagonizing the action of the replicative helicase (thereby exhibiting a contrahelicase activity). Terminator proteins also arrest RNA polymerases in a polar fashion. Passage of an RNA transcript through a terminus from the non-blocking direction abrogates replication termination function, a mechanism that is likely to be used in conditional termini or replication check points.
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