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Review

. 1999 May;64(5):1264-9.

doi: 10.1086/302391.

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

Affiliations

PMID: 10205255
PMCID: PMC1377860
DOI: 10.1086/302391

Review

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

J H Petrini. Am J Hum Genet. 1999 May.

. 1999 May;64(5):1264-9.

doi: 10.1086/302391.

Author

Affiliation

¹ Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.

PMID: 10205255
PMCID: PMC1377860
DOI: 10.1086/302391

No abstract available

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References

1. Cell. 1983 May;33(1):25-35 - PubMed
1. Semin Cancer Biol. 1993 Apr;4(2):73-83 - PubMed
1. Mutat Res. 1986 Dec;163(3):255-62 - PubMed
1. Am J Med Sci. 1988 Jan;295(1):40-8 - PubMed
1. Birth Defects Orig Artic Ser. 1989;25(2):61-82 - PubMed

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