Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jan;28(1):29-33.
doi: 10.1093/ageing/28.1.29.

Total and functional hepatic blood flow decrease in parallel with ageing

M Zoli  1 , D Magalotti, G Bianchi, C Gueli, C Orlandini, M Grimaldi, G Marchesini
Affiliations

Total and functional hepatic blood flow decrease in parallel with ageing

M Zoli et al. Age Ageing. 1999 Jan.

Abstract

Objectives: To study changes in hepatic blood flow with age.

Design: Functional hepatic flow (FHF) and total hepatic flow (THF) were determined by non-invasive methods in 40 normal subjects in four age groups (<45, 45-60, 61-75 and >75 years). All subjects had normal routine liver function tests and no history of liver disease.

Results: THF was measured by pulsed echo-Doppler, as the sum of portal and hepatic artery blood flow; FHF was measured by the hepatic clearance of D-sorbitol. THF significantly decreased with age, particularly in subjects over 75 (from 1445+/-220 ml/min to 1020+/-148; P<0.001), and a similar reduction was observed in FHF (from 1514+/-250 ml/min to 1015+/-163; P<0.001). THF and FHF were strictly correlated in the whole population (r = 0.871; P<0.001) and both correlated with age (r = -0.510 and r = -0.596; P<0.005).

Conclusion: With ageing there is a reduction of hepatic blood flow without any additional intrahepatic shunting.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution.
    Snoeijink TJ, Vlogman TG, Roosen J, Groot Jebbink E, Jain K, Nijsen JFW. Snoeijink TJ, et al. Drug Deliv. 2023 Dec;30(1):2226366. doi: 10.1080/10717544.2023.2226366. Drug Deliv. 2023. PMID: 37341184 Free PMC article.
  • Biomarkers of aging.
    Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Ci W, Ding BS, Ding Q, Gao F, Han JJ, Huang K, Ju Z, Kong QP, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun YE, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH. Aging Biomarker Consortium, et al. Sci China Life Sci. 2023 May;66(5):893-1066. doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11. Sci China Life Sci. 2023. PMID: 37076725 Free PMC article. Review.
  • Liver function and phase I drug metabolism in the elderly: a paradox.
    Schmucker DL. Schmucker DL. Drugs Aging. 2001;18(11):837-51. doi: 10.2165/00002512-200118110-00005. Drugs Aging. 2001. PMID: 11772124 Review.
  • Cirrhotic patients and older people.
    Carrier P, Debette-Gratien M, Jacques J, Loustaud-Ratti V. Carrier P, et al. World J Hepatol. 2019 Sep 27;11(9):663-677. doi: 10.4254/wjh.v11.i9.663. World J Hepatol. 2019. PMID: 31598192 Free PMC article. Review.
  • Under-representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database.
    Ruiter R, Burggraaf J, Rissmann R. Ruiter R, et al. Br J Clin Pharmacol. 2019 Apr;85(4):838-844. doi: 10.1111/bcp.13876. Epub 2019 Feb 23. Br J Clin Pharmacol. 2019. PMID: 30681181 Free PMC article.
See all "Cited by" articles

Publication types

LinkOut - more resources