Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
- PMID: 10195220
- DOI: 10.1038/6368
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
Abstract
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving newborn cells, in amounts similar to enrichment conditions. Our findings demonstrate that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus.
Comment in
-
New neurons in old brains: learning to survive?Nat Neurosci. 1999 Mar;2(3):203-5. doi: 10.1038/6300. Nat Neurosci. 1999. PMID: 10195209 No abstract available.
-
Outsmarting (and outrunning) nature's harsh decree.Nat Neurosci. 2018 Sep;21(9):1141-1142. doi: 10.1038/s41593-018-0214-1. Nat Neurosci. 2018. PMID: 30127426 No abstract available.
Similar articles
-
Mouse genetic differences in voluntary wheel running, adult hippocampal neurogenesis and learning on the multi-strain-adapted plus water maze.Behav Brain Res. 2015 Mar 1;280:62-71. doi: 10.1016/j.bbr.2014.11.030. Epub 2014 Nov 27. Behav Brain Res. 2015. PMID: 25435316 Free PMC article.
-
Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner.Hippocampus. 2016 Mar;26(3):282-8. doi: 10.1002/hipo.22551. Epub 2015 Dec 8. Hippocampus. 2016. PMID: 26606164
-
Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain.Hippocampus. 2009 Oct;19(10):937-50. doi: 10.1002/hipo.20543. Hippocampus. 2009. PMID: 19132736 Free PMC article.
-
Learning and adult neurogenesis: survival with or without proliferation?Neurobiol Learn Mem. 2004 Jan;81(1):1-11. doi: 10.1016/j.nlm.2003.09.001. Neurobiol Learn Mem. 2004. PMID: 14670353 Review.
-
Neurogenesis in adult mammals: some progress and problems.J Neurosci. 2002 Feb 1;22(3):619-23. doi: 10.1523/JNEUROSCI.22-03-00619.2002. J Neurosci. 2002. PMID: 11826089 Free PMC article. Review. No abstract available.
Cited by
-
Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits.Front Behav Neurosci. 2024 Oct 17;18:1478656. doi: 10.3389/fnbeh.2024.1478656. eCollection 2024. Front Behav Neurosci. 2024. PMID: 39494036 Free PMC article.
-
Oxidative Stress and Adult Neurogenesis.Stem Cell Rev Rep. 2015 Oct;11(5):706-9. doi: 10.1007/s12015-015-9603-y. Stem Cell Rev Rep. 2015. PMID: 26100529 Review.
-
The efficacy of traditional Chinese Medical Exercise for Parkinson's disease: a systematic review and meta-analysis.PLoS One. 2015 Apr 1;10(4):e0122469. doi: 10.1371/journal.pone.0122469. eCollection 2015. PLoS One. 2015. PMID: 25830664 Free PMC article. Review.
-
Different Mechanisms Must Be Considered to Explain the Increase in Hippocampal Neural Precursor Cell Proliferation by Physical Activity.Front Neurosci. 2016 Aug 3;10:362. doi: 10.3389/fnins.2016.00362. eCollection 2016. Front Neurosci. 2016. PMID: 27536215 Free PMC article. Review.
-
Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice.Nutrients. 2020 Jun 15;12(6):1777. doi: 10.3390/nu12061777. Nutrients. 2020. PMID: 32549250 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
