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Comparative Study
. 1999 Jan;13(1):38-43.
doi: 10.1038/sj.leu.2401241.

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

T Iwai  1 , S Yokota, M Nakao, T Okamoto, M Taniwaki, N Onodera, A Watanabe, A Kikuta, A Tanaka, K Asami, I Sekine, H Mugishima, Y Nishimura, S Koizumi, Y Horikoshi, J Mimaya, S Ohta, K Nishikawa, A Iwai, T Shimokawa, M Nakayama, K Kawakami, T Gushiken, N Hyakuna, T Fujimoto, et al.
Affiliations
Comparative Study

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

T Iwai et al. Leukemia. 1999 Jan.

Abstract

We analyzed tandem duplication in the juxtamembrane (JM) domain of the FLT3 (FMS-like tyrosine kinase 3/FLK2, CD135) gene in 94 children with acute myeloid leukemia (AML) and evaluated its correlation with clinical features. Longer polymerase chain reaction (PCR) products were observed in five patients; 1/3 of M0, 119 of M1, 1/39 of M2, 1/9 of M3 and 1/12 of M5. The sequence analyses of abnormal PCR products showed that all the abnormal products were derived from tandem duplications involving the JM domain and that all the lengthened sequences were in-frame as we previously reported. Statistical analyses revealed a significantly lower incidence of the tandem duplication in childhood AML patients than in adult patients (P < 0.05), and significantly shorter disease-free survival in patients with mutant FLT3 than in patients with wild-type FLT3 (P < 0.05). Our results suggest that the tandem duplication in the JM domain of the FLT3 gene is not a frequent phenomenon but might be a factor of poor prognosis in childhood patients with AML.

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