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Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis.
Lee TC, Murthy S, Del Corpo O, Senécal J, Butler-Laporte G, Sohani ZN, Brophy JM, McDonald EG. Lee TC, et al. Clin Microbiol Infect. 2022 Sep;28(9):1203-1210. doi: 10.1016/j.cmi.2022.04.018. Epub 2022 May 19. Clin Microbiol Infect. 2022. PMID: 35598856 Free PMC article. Review.
OBJECTIVES: To evaluate the role of remdesivir for hospitalized inpatients as a function of oxygen requirements. ...The probability that remdesivir reduced mortality by 1% was 77.4% for nonventilated patients requiring oxygen. ...
OBJECTIVES: To evaluate the role of remdesivir for hospitalized inpatients as a function of oxygen requirements. ...The probability t …
Retrospective study and outcome of 307 cats with feline infectious peritonitis treated with legally sourced veterinary compounded preparations of remdesivir and GS-441524 (2020-2022).
Taylor SS, Coggins S, Barker EN, Gunn-Moore D, Jeevaratnam K, Norris JM, Hughes D, Stacey E, MacFarlane L, O'Brien C, Korman R, McLauchlan G, Salord Torres X, Taylor A, Bongers J, Espada Castro L, Foreman M, McMurrough J, Thomas B, Royaux E, Calvo Saiz I, Bertoldi G, Harlos C, Work M, Prior C, Sorrell S, Malik R, Tasker S. Taylor SS, et al. J Feline Med Surg. 2023 Sep;25(9):1098612X231194460. doi: 10.1177/1098612X231194460. J Feline Med Surg. 2023. PMID: 37732386 Free PMC article.
RESULTS: Among the 307 cats recruited, the predominant type of FIP was most commonly abdominal effusive (49.5%) and then neurological (14.3%). Three treatment protocols were used; remdesivir alone (33.9%), remdesivir followed by GS-441524 (55.7%) and GS-441524 alone …
RESULTS: Among the 307 cats recruited, the predominant type of FIP was most commonly abdominal effusive (49.5%) and then neurological (14.3% …
Remdesivir for the treatment of COVID-19.
Grundeis F, Ansems K, Dahms K, Thieme V, Metzendorf MI, Skoetz N, Benstoem C, Mikolajewska A, Griesel M, Fichtner F, Stegemann M. Grundeis F, et al. Cochrane Database Syst Rev. 2023 Jan 25;1(1):CD014962. doi: 10.1002/14651858.CD014962.pub2. Cochrane Database Syst Rev. 2023. PMID: 36695483 Free PMC article. Review.
BACKGROUND: Remdesivir is an antiviral medicine approved for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19). ...The hospitalisation rate was reduced with remdesivir in one study including participants with mild to moderate COVID-19. ...
BACKGROUND: Remdesivir is an antiviral medicine approved for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19). . …
Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524.
Green J, Syme H, Tayler S. Green J, et al. J Vet Intern Med. 2023 Sep-Oct;37(5):1784-1793. doi: 10.1111/jvim.16804. Epub 2023 Jul 4. J Vet Intern Med. 2023. PMID: 37403259 Free PMC article.
BACKGROUND: GS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, remdesivir, in combination with a PO GS-441524 containing product for the treatment of FIP has not yet been described. ...RESULTS: Cats r …
BACKGROUND: GS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. However, the use of its prodrug, r …
Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524.
Coggins SJ, Norris JM, Malik R, Govendir M, Hall EJ, Kimble B, Thompson MF. Coggins SJ, et al. J Vet Intern Med. 2023 Sep-Oct;37(5):1772-1783. doi: 10.1111/jvim.16803. Epub 2023 Jul 13. J Vet Intern Med. 2023. PMID: 37439383 Free PMC article.
BACKGROUND: Nucleoside analog GS-441524 is effective in treating cats with feline infectious peritonitis (FIP). Investigation into the use of parent nucleotide analog remdesivir (GS-5734) is needed. OBJECTIVES: To assess efficacy and tolerability of remdesivir with …
BACKGROUND: Nucleoside analog GS-441524 is effective in treating cats with feline infectious peritonitis (FIP). Investigation into the use o …
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.
Spinner CD, Gottlieb RL, Criner GJ, Arribas López JR, Cattelan AM, Soriano Viladomiu A, Ogbuagu O, Malhotra P, Mullane KM, Castagna A, Chai LYA, Roestenberg M, Tsang OTY, Bernasconi E, Le Turnier P, Chang SC, SenGupta D, Hyland RH, Osinusi AO, Cao H, Blair C, Wang H, Gaggar A, Brainard DM, McPhail MJ, Bhagani S, Ahn MY, Sanyal AJ, Huhn G, Marty FM; GS-US-540-5774 Investigators. Spinner CD, et al. JAMA. 2020 Sep 15;324(11):1048-1057. doi: 10.1001/jama.2020.16349. JAMA. 2020. PMID: 32821939 Free PMC article. Clinical Trial.
Median length of treatment was 5 days for patients in the 5-day remdesivir group and 6 days for patients in the 10-day remdesivir group. ...By day 28, 9 patients had died: 2 (1%) in the 5-day remdesivir group, 3 (2%) in the 10-day remdesivir group, and …
Median length of treatment was 5 days for patients in the 5-day remdesivir group and 6 days for patients in the 10-day remdesivir …
Remdesivir and Its Combination With Repurposed Drugs as COVID-19 Therapeutics.
Chatterjee B, Thakur SS. Chatterjee B, et al. Front Immunol. 2022 May 12;13:830990. doi: 10.3389/fimmu.2022.830990. eCollection 2022. Front Immunol. 2022. PMID: 35634324 Free PMC article. Review.
Better results were obtained with the remdesivir-baricitinib combination treatment for COVID-19 compared to the treatment with remdesivir alone. ...Furthermore, the mortality rate via the remdesivir-baricitinib combination treatment was lower compared to the …
Better results were obtained with the remdesivir-baricitinib combination treatment for COVID-19 compared to the treatment with rem …
Remdesivir-Induced Bradycardia.
Kanagala SG, Dholiya H, Jhajj P, Patel MA, Gupta V, Gupta S, Wu SI, Jain R. Kanagala SG, et al. South Med J. 2023 Mar;116(3):317-320. doi: 10.14423/SMJ.0000000000001519. South Med J. 2023. PMID: 36863055 Free PMC article. Review.
Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved t …
Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because …
Remdesivir and COVID-19.
Glaus MJ, Von Ruden S. Glaus MJ, et al. Lancet. 2020 Oct 3;396(10256):952. doi: 10.1016/S0140-6736(20)32021-3. Lancet. 2020. PMID: 33010831 Free PMC article. No abstract available.
Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19.
Kaur A, Chaudhary G, Singh P, Arora S, Kaur R. Kaur A, et al. Curr Drug Targets. 2021;22(13):1536-1547. doi: 10.2174/1389450121999201228212842. Curr Drug Targets. 2021. PMID: 33371833 Review.
RESULTS: This study indicates that 5 out of 10 works of literature find that Remdesivir leads to a reduction in recovery time, and the remaining 5 pieces of literature found Remdesivir to have no variance and have limitations. ...CONCLUSION: There is a need to asses …
RESULTS: This study indicates that 5 out of 10 works of literature find that Remdesivir leads to a reduction in recovery time, and th …
4,113 results