Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1983 2
1984 3
1985 1
1986 2
1987 2
1988 1
1989 5
1990 15
1991 31
1992 45
1993 52
1994 82
1995 90
1996 104
1997 104
1998 125
1999 113
2000 128
2001 161
2002 134
2003 149
2004 136
2005 132
2006 124
2007 145
2008 162
2009 160
2010 175
2011 217
2012 201
2013 204
2014 209
2015 220
2016 205
2017 193
2018 186
2019 186
2020 156
2021 169
2022 56
2023 29
2024 57

Text availability

Article attribute

Article type

Publication date

Search Results

4,299 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Tumor-Suppressor Functions of the TP53 Pathway.
Aubrey BJ, Strasser A, Kelly GL. Aubrey BJ, et al. Cold Spring Harb Perspect Med. 2016 May 2;6(5):a026062. doi: 10.1101/cshperspect.a026062. Cold Spring Harb Perspect Med. 2016. PMID: 27141080 Free PMC article. Review.
This is confirmed in animal models, in which a defective Tp53 gene leads inexorably to cancer development, whereas reinstatement of TP53 function results in regression of established tumors that had been initiated by loss of TP53. Remarkably, despite extensive inves …
This is confirmed in animal models, in which a defective Tp53 gene leads inexorably to cancer development, whereas reinstateme …
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis.
Tamura R. Tamura R. Int J Mol Sci. 2021 May 29;22(11):5850. doi: 10.3390/ijms22115850. Int J Mol Sci. 2021. PMID: 34072574 Free PMC article. Review.
The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as a negative regulator of Ras/MAPK and PI3K/mTOR signaling pathways. ...In contrast, molecular insights on the different forms of SWN remain u …
The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as …
Neurofibromatosis type 1.
Cimino PJ, Gutmann DH. Cimino PJ, et al. Handb Clin Neurol. 2018;148:799-811. doi: 10.1016/B978-0-444-64076-5.00051-X. Handb Clin Neurol. 2018. PMID: 29478615 Review.
However, recent studies aimed at understanding the role of the NF1 protein (neurofibromin) as a tumor suppressor have revealed that this profound level of clinical heterogeneity may reflect tissue and region-specific effects, sexually dimorphic influences, and the c …
However, recent studies aimed at understanding the role of the NF1 protein (neurofibromin) as a tumor suppressor have revealed …
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. Jonkers J, et al. Nat Genet. 2001 Dec;29(4):418-25. doi: 10.1038/ng747. Nat Genet. 2001. PMID: 11694875 Free article.
The presence of one wildtype Brca2 allele resulted in a markedly delayed tumor formation; loss of the wildtype Brca2 allele occurred in a subset of these tumors. ...
The presence of one wildtype Brca2 allele resulted in a markedly delayed tumor formation; loss of the wildtype Brca2 allele occurred …
Animal models of tumor-suppressor genes.
Hakem R, Mak TW. Hakem R, et al. Annu Rev Genet. 2001;35:209-41. doi: 10.1146/annurev.genet.35.102401.090432. Annu Rev Genet. 2001. PMID: 11700283 Review.
The availability of null and tissue-specific mouse mutants for tumor-suppressor genes has greatly facilitated our understanding of the mechanisms leading to cancer. In this review, we describe mouse models for tumor-suppressor genes …
The availability of null and tissue-specific mouse mutants for tumor-suppressor genes has greatly facilitated our under …
Analyses of tumor-suppressor genes in germline mouse models of cancer.
Wang J, Abate-Shen C. Wang J, et al. Cold Spring Harb Protoc. 2014 Aug 1;2014(8):807-12. doi: 10.1101/pdb.top069773. Cold Spring Harb Protoc. 2014. PMID: 25086022 Free PMC article.
Tumor-suppressor genes are critical regulators of growth and functioning of cells, whose loss of function contributes to tumorigenesis. ...Nowadays, most investigations of genetically engineered mouse models of tumor-suppressor function u …
Tumor-suppressor genes are critical regulators of growth and functioning of cells, whose loss of function contributes t …
Common fragile site tumor suppressor genes and corresponding mouse models of cancer.
Drusco A, Pekarsky Y, Costinean S, Antenucci A, Conti L, Volinia S, Aqeilan RI, Huebner K, Zanesi N. Drusco A, et al. J Biomed Biotechnol. 2011;2011:984505. doi: 10.1155/2011/984505. Epub 2010 Dec 29. J Biomed Biotechnol. 2011. PMID: 21318118 Free PMC article. Review.
Interestingly, several CFSs contain one or more tumor suppressor genes whose structure and function are often affected by chromosomal fragility. The two most active fragile sites in the human genome are FRA3B and FRA16D where the tumor suppressor …
Interestingly, several CFSs contain one or more tumor suppressor genes whose structure and function are often affected …
Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models.
Rouland L, Duplan E, Ramos Dos Santos L, Bernardin A, Katula KS, Manfioletti G, Idbaih A, Checler F, Alves da Costa C. Rouland L, et al. Theranostics. 2021 Nov 1;11(20):10047-10063. doi: 10.7150/thno.57549. eCollection 2021. Theranostics. 2021. PMID: 34815803 Free PMC article.
Parkin (PK) is an E3-ligase harboring tumor suppressor properties that has been associated to various cancer types including glioblastoma (GBM). ...Conclusion: Our work demonstrates that PK tumor suppressor function contributes to the control of tum …
Parkin (PK) is an E3-ligase harboring tumor suppressor properties that has been associated to various cancer types including g …
Murine tumor suppressor models.
Venkatachalam S, Donehower LA. Venkatachalam S, et al. Mutat Res. 1998 May 25;400(1-2):391-407. doi: 10.1016/s0027-5107(98)00018-9. Mutat Res. 1998. PMID: 9685699 Review.
Tumor suppressor genes have been shown to be necessary for proper maintenance of cell growth control. ...During the past few years, advances in molecular and cellular biology have led to the creation of animal models that have germline mutations …
Tumor suppressor genes have been shown to be necessary for proper maintenance of cell growth control. ...During the pas …
LKB1 modulates lung cancer differentiation and metastasis.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. Ji H, et al. Nature. 2007 Aug 16;448(7155):807-10. doi: 10.1038/nature06030. Epub 2007 Aug 5. Nature. 2007. PMID: 17676035
Expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes, such as NEDD9, VEGFC and CD24, as targets of LKB1 repression in lung cancer. These studies establish LKB1 as a critical barrier to pulmonary tumo …
Expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes, such …
4,299 results