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Review
. 1999 Jan;6(1):59-66.
doi: 10.1016/s0929-693x(99)80076-1.

[Treatment of infantile visceral leishmaniasis]

[Article in French]
P Minodier  1 , F Faraut-Gambarelli, R Piarroux, C Gire, J M Garnier, H Dumon
Affiliations
Review

[Treatment of infantile visceral leishmaniasis]

[Article in French]
P Minodier et al. Arch Pediatr. 1999 Jan.

Abstract

Visceral leishmaniasis is an endemic disease in the Mediterranean Basin. Children are one of the targets of the infection. Treatment usually requires parenteral injections of pentavalent antimony (Glucantime or Pentostam), but the high frequency of adverse events and the occurrence of primary or secondary resistance cases limit the use of these medications. Diamidines (Pentacarinat) or amphotericin B derivatives are alternatives to antimony. Unfortunately, pharmacokinetics and optimal dosage of diamidines are not well-known, and numerous adverse events are described. Liposomal preparations of amphotericin B enhance its efficiency and tolerance, and the duration of treatment may be reduced to 5 days. Moreover, primary resistance to amphotericin B is not described in immunocompetent children. Allopurinol associated with antimony seems no more efficient than antimony alone. Aminosidine is not evaluated.

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