Molecular mechanisms of angiotensin II receptor internalization
- PMID: 9892140
Molecular mechanisms of angiotensin II receptor internalization
Abstract
Angiotensin II (AngII) initiates cellular responses by activation of type I (AT1) and type 2 (AT2) angiotensin receptors. Both AT1 and AT1 receptors have seven transmembrane structures characteristic of G protein-coupled receptors, but only the AT1 receptor undergoes rapid internalization upon agonist binding. In addition to the agonist hormone, the peptide antagonist [Sar1,Ile8]AngII can also induce internalization of the AT1a receptor expressed in mammalian cell lines, but the nonpeptide AT1 receptor blocker losartan does not internalize. AT1 receptor internalization occurs via clathrin-coated pits, but there is evidence that, in contrast to the internalization of other G protein-coupled receptors, the internalization of the AT1 receptor is independent of dynamin and beta-arrestin. Mutagenesis studies demonstrated that AT1 receptor internalization requires two regions in the cytoplasmic tail of the receptor, but it is independent of G protein activation. The dependence of AT1 receptor internalization on the presence of a serine-threonine-rich region suggests that phosphorylation of the receptor tail may regulate the internalization process. The possible role of AT1 receptor internalization in sustained signal generation has been suggested, but its relationship to nuclear AngII receptors is not completely understood.
Similar articles
-
Molecular mechanisms of angiotensin II (AT1A) receptor endocytosis.Clin Exp Pharmacol Physiol Suppl. 1996;3:S74-80. Clin Exp Pharmacol Physiol Suppl. 1996. PMID: 8993843 Review.
-
Molecular mechanisms of angiotensin II (AT1a) receptor endocytosis.Clin Exp Pharmacol Physiol. 1996 Sep;23 Suppl 3:S74-80. doi: 10.1111/j.1440-1681.1996.tb02817.x. Clin Exp Pharmacol Physiol. 1996. PMID: 21143277 Review.
-
Structural determinants of agonist-induced signaling and regulation of the angiotensin AT1 receptor.Mol Cell Endocrinol. 2004 Mar 31;217(1-2):89-100. doi: 10.1016/j.mce.2003.10.014. Mol Cell Endocrinol. 2004. PMID: 15134806
-
The angiotensin II type 1 receptor and receptor-associated proteins.Cell Res. 2001 Sep;11(3):165-80. doi: 10.1038/sj.cr.7290083. Cell Res. 2001. PMID: 11642401 Review.
-
Several interesting phenotypes of the AT1 receptor produced by site-directed mutagenesis.J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S8-14. J Am Soc Nephrol. 1999. PMID: 9892134 Review.
Cited by
-
Protein-peptide complexes of angiotensins in the mechanisms of thirst motivation.Neurosci Behav Physiol. 2003 Oct;33(8):811-9. doi: 10.1023/a:1025105617037. Neurosci Behav Physiol. 2003. PMID: 14635998
-
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors.J Biol Chem. 2011 Feb 18;286(7):5319-27. doi: 10.1074/jbc.M110.176933. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21062747 Free PMC article.
-
Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity.Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C615-27. doi: 10.1152/ajpcell.00193.2011. Epub 2011 Nov 2. Am J Physiol Cell Physiol. 2012. PMID: 22049215 Free PMC article.
-
MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2-Dependent Pathway.Hypertension. 2017 Nov;70(5):982-989. doi: 10.1161/HYPERTENSIONAHA.117.09789. Epub 2017 Sep 5. Hypertension. 2017. PMID: 28874464 Free PMC article.
-
The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system.Cell Death Dis. 2017 Sep 7;8(9):e3044. doi: 10.1038/cddis.2017.439. Cell Death Dis. 2017. PMID: 28880266 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
