Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex
- PMID: 9835636
- DOI: 10.1006/scdb.1998.0256
Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex
Abstract
Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.
Copyright 1998 Academic Press.
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