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Review
. 1998 Oct;9(5):493-501.
doi: 10.1006/scdb.1998.0256.

Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex

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Review

Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex

W Nickel et al. Semin Cell Dev Biol. 1998 Oct.

Abstract

Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.

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