Origin and roles of genomic methylation patterns in male germ cells
- PMID: 9813194
- DOI: 10.1006/scdb.1998.0225
Origin and roles of genomic methylation patterns in male germ cells
Abstract
The epigenetic modification of DNA by methylation at cytosine residues is initiated in the germ line and is required for normal embryonic development in mammals. Marked differences in genomic methylation between male and female gametes arise during gametogenesis and have been implicated in genomic imprinting. While DNA methylation patterns for different types of gene sequences are known to change during spermatogenesis, the precise role(s) of DNA methylation in the normal development of male germ cells is poorly understood. The expression of the one known active form of DNA methyltransferase is highly regulated during spermatogenesis and may provide insight into mechanisms underlying the establishment of methylation patterns in germ cells.
Copyright 1998 Academic Press.
Comment in
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Introduction: the male germ cell; origin, migration, proliferation and differentiation.Semin Cell Dev Biol. 1998 Aug;9(4):379-91. doi: 10.1006/scdb.1998.0254. Semin Cell Dev Biol. 1998. PMID: 9813185 No abstract available.
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