Review
doi: 10.1006/scdb.1998.0203.
The central role of Sertoli cells in spermatogenesis
Affiliations
- PMID: 9813187
- DOI: 10.1006/scdb.1998.0203
Item in Clipboard
Review
The central role of Sertoli cells in spermatogenesis
Semin Cell Dev Biol.
1998 Aug.
Abstract
Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules. The regulation of spermatogenesis by FSH and testosterone occurs by the action of these hormones on the Sertoli cells. While the action of testosterone is necessary for spermatogenesis, the action of FSH minimally serves to promote spermatogenic output by increasing the number of Sertoli cells.
Copyright 1998 Academic Press.
Comment in
-
Introduction: the male germ cell; origin, migration, proliferation and differentiation.Semin Cell Dev Biol. 1998 Aug;9(4):379-91. doi: 10.1006/scdb.1998.0254. Semin Cell Dev Biol. 1998. PMID: 9813185 No abstract available.
Similar articles
-
Role of Sertoli cell number and function on regulation of spermatogenesis.Anim Reprod Sci. 2008 Apr;105(1-2):23-51. doi: 10.1016/j.anireprosci.2007.11.029. Epub 2007 Dec 15. Anim Reprod Sci. 2008. PMID: 18242891 Review.
-
[Organization and regulation of spermatogenesis].Nihon Rinsho. 1997 Nov;55(11):2816-21. Nihon Rinsho. 1997. PMID: 9396270 Review. Japanese.
-
Paracrine interaction in testicular somatic cells.Ital J Anat Embryol. 1998;103(4 Suppl 1):139-52. Ital J Anat Embryol. 1998. PMID: 11315945
-
The effects of postnatal FSH substitution on Sertoli cell number and the sperm production capacity of the adult boar.Anim Reprod Sci. 2009 Feb;110(3-4):269-82. doi: 10.1016/j.anireprosci.2008.01.017. Epub 2008 Feb 2. Anim Reprod Sci. 2009. PMID: 18321668
-
Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells.Biol Reprod. 2003 Sep;69(3):1069-78. doi: 10.1095/biolreprod.102.010074. Epub 2003 May 28. Biol Reprod. 2003. PMID: 12773420
Cited by
-
Busulfan Chemotherapy Downregulates TAF7/TNF-α Signaling in Male Germ Cell Dysfunction.Biomedicines. 2024 Sep 28;12(10):2220. doi: 10.3390/biomedicines12102220. Biomedicines. 2024. PMID: 39457533 Free PMC article.
-
The effect of amantadine on clomipramine induced sexual dysfunction in male rats.Oman Med J. 2011 Nov;26(6):404-9. doi: 10.5001/omj.2011.104. Oman Med J. 2011. PMID: 22253948 Free PMC article.
-
Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis.PLoS One. 2013 May 7;8(5):e63603. doi: 10.1371/journal.pone.0063603. Print 2013. PLoS One. 2013. PMID: 23667645 Free PMC article.
-
A Normative Model of Serum Inhibin B in Young Males.PLoS One. 2016 Apr 14;11(4):e0153843. doi: 10.1371/journal.pone.0153843. eCollection 2016. PLoS One. 2016. PMID: 27077369 Free PMC article.
-
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro.Development. 2022 Nov 15;149(22):dev200713. doi: 10.1242/dev.200713. Epub 2022 Nov 16. Development. 2022. PMID: 36250451 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
