Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Nov 13;282(5392):1332-4.
doi: 10.1126/science.282.5392.1332.

Reovirus therapy of tumors with activated Ras pathway

M C Coffey  1 , J E Strong, P A Forsyth, P W Lee
Affiliations

Reovirus therapy of tumors with activated Ras pathway

M C Coffey et al. Science. .

Abstract

Human reovirus requires an activated Ras signaling pathway for infection of cultured cells. To investigate whether this property can be exploited for cancer therapy, severe combined immune deficient mice bearing tumors established from v-erbB-transformed murine NIH 3T3 cells or human U87 glioblastoma cells were treated with the virus. A single intratumoral injection of virus resulted in regression of tumors in 65 to 80 percent of the mice. Treatment of immune-competent C3H mice bearing tumors established from ras-transformed C3H-10T1/2 cells also resulted in tumor regression, although a series of injections were required. These results suggest that, with further work, reovirus may have applicability in the treatment of cancer.

PubMed Disclaimer

Comment in

  • Training viruses to attack cancers.
    Pennisi E. Pennisi E. Science. 1998 Nov 13;282(5392):1244-6. doi: 10.1126/science.282.5392.1244. Science. 1998. PMID: 9867627 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources