Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
- PMID: 9809962
- DOI: 10.1016/s0735-1097(98)00407-0
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
Abstract
Objectives: This study examined the relations of echocardiographically determined left ventricular (LV) mass and hypertrophy to the risk of sudden death.
Background: Echocardiographic LV hypertrophy is associated with increased risk for all-cause mortality and cardiovascular disease morbidity and mortality. However, little is known about the association of echocardiographic LV hypertrophy with sudden death.
Methods: We examined the relations of LV mass and hypertrophy to the incidence of sudden death in 3,661 subjects enrolled in the Framingham Heart Study who were > or =40 years of age. The baseline examination was performed from 1979 to 1983 and LV hypertrophy was defined as LV mass (adjusted for height) > 143 g/m in men and > 102 g/m in women. During up to 14 years of follow-up there were 60 sudden deaths. Cox models examined the relations of LV mass and LV hypertrophy to sudden death risk after adjusting for known risk factors.
Results: The prevalence of LV hypertrophy was 21.5%. The risk factor-adjusted hazard ratio (HR) for sudden death was 1.45 (95% confidence interval [CI] 1.10 to 1.92, p=0.008) for each 50-g/m increment in LV mass. For LV hypertrophy, the risk factor-adjusted HR for sudden death was 2.16 (95% CI 1.22 to 3.81, p=0.008). After excluding the first 4 years of follow-up, both increased LV mass and LV hypertrophy conferred long-term risk of sudden death (HR 1.53, 95% CI 1.01 to 2.28, p=0.047 and HR 3.28, 95% CI 1.58 to 6.83, p=0.002, respectively).
Conclusions: Increased LV mass and hypertrophy are associated with increased risk for sudden death after accounting for known risk factors.
Comment in
-
Left ventricular hypertrophy and sudden death.J Am Coll Cardiol. 1998 Nov;32(5):1460-2. doi: 10.1016/s0735-1097(98)00414-8. J Am Coll Cardiol. 1998. PMID: 9809963 No abstract available.
-
Left ventricular hypertrophy and sudden death.J Am Coll Cardiol. 1999 Jun;33(7):2089. J Am Coll Cardiol. 1999. PMID: 10362223 No abstract available.
Similar articles
-
Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study).Am J Cardiol. 2008 Nov 1;102(9):1131-5. doi: 10.1016/j.amjcard.2008.06.036. Epub 2008 Aug 27. Am J Cardiol. 2008. PMID: 18940278 Free PMC article.
-
Asymptomatic ventricular arrhythmias and mortality risk in subjects with left ventricular hypertrophy.J Am Coll Cardiol. 1993 Oct;22(4):1111-6. doi: 10.1016/0735-1097(93)90424-y. J Am Coll Cardiol. 1993. PMID: 8409049
-
Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study.JACC Cardiovasc Imaging. 2008 Sep;1(5):582-91. doi: 10.1016/j.jcmg.2008.05.012. JACC Cardiovasc Imaging. 2008. PMID: 19356485 Clinical Trial.
-
Association of left ventricular dilatation and hypertrophy with chronotropic incompetence in the Framingham Heart Study.Am Heart J. 1999 May;137(5):903-9. doi: 10.1016/s0002-8703(99)70415-1. Am Heart J. 1999. PMID: 10220640
-
Screening for sudden death in young patients.Semin Pediatr Neurol. 2005 Mar;12(1):39-51. doi: 10.1016/j.spen.2005.02.001. Semin Pediatr Neurol. 2005. PMID: 15929464 Review. No abstract available.
Cited by
-
Impact of regional left ventricular function on outcome for patients with AL amyloidosis.PLoS One. 2013;8(3):e56923. doi: 10.1371/journal.pone.0056923. Epub 2013 Mar 8. PLoS One. 2013. PMID: 23520459 Free PMC article. Clinical Trial.
-
Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy.Front Pharmacol. 2023 Nov 22;14:1264216. doi: 10.3389/fphar.2023.1264216. eCollection 2023. Front Pharmacol. 2023. PMID: 38074139 Free PMC article.
-
Deep Learning to Predict Cardiac Magnetic Resonance-Derived Left Ventricular Mass and Hypertrophy From 12-Lead ECGs.Circ Cardiovasc Imaging. 2021 Jun;14(6):e012281. doi: 10.1161/CIRCIMAGING.120.012281. Epub 2021 Jun 15. Circ Cardiovasc Imaging. 2021. PMID: 34126762 Free PMC article.
-
Recent Non-Invasive Parameters to Identify Subjects at High Risk of Sudden Cardiac Death.J Clin Med. 2022 Mar 10;11(6):1519. doi: 10.3390/jcm11061519. J Clin Med. 2022. PMID: 35329848 Free PMC article. Review.
-
Cost-effectiveness of in-home automated external defibrillators for individuals at increased risk of sudden cardiac death.J Gen Intern Med. 2005 Mar;20(3):251-8. doi: 10.1111/j.1525-1497.2005.40247.x. J Gen Intern Med. 2005. PMID: 15836529 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
