Recent advances in the understanding of interleukin-2 signal transduction
- PMID: 9793823
- DOI: 10.1023/a:1023223614407
Recent advances in the understanding of interleukin-2 signal transduction
Abstract
Interleukin-2 is one of the critical cytokines that control the proliferation and differentiation of cells of the immune system. The present article briefly reviews the current and recently established knowledge on the intracellular signaling events that convert the initial interaction of IL-2 with its receptor into pathways leading to the various biological functions. A first step in IL-2 signaling is the activation of several protein tyrosine kinases that phosphorylate a large array of intracellular substrates including the receptor complex. Phosphorylated tyrosine residues within the receptor then serve as docking sites for multimolecular signaling complexes that initiate three major pathways: the Jak-STAT pathway controlling gene transcription, the Ras-MAPK pathway leading to cell proliferation and gene transcription as well, and the PI3-kinase pathway involved in antiapoptotic signaling and organization of the cytoskeleton. Finally, other recently identified and presumably important tyrosine kinase substrates, whose significance is not yet fully understood, are described.
Similar articles
-
Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.Cancer Res. 2001 Jan 1;61(1):383-91. Cancer Res. 2001. PMID: 11196191
-
IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.J Immunol. 1999 Feb 15;162(4):2081-6. J Immunol. 1999. PMID: 9973481
-
Signaling from the IL-2 receptor to the nucleus.Cytokine Growth Factor Rev. 1997 Dec;8(4):313-32. doi: 10.1016/s1359-6101(97)00021-x. Cytokine Growth Factor Rev. 1997. PMID: 9620644 Review.
-
Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling.Oncogene. 2003 Sep 4;22(38):5995-6004. doi: 10.1038/sj.onc.1206846. Oncogene. 2003. PMID: 12955078
-
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Oncogene. 2000 May 15;19(21):2532-47. doi: 10.1038/sj.onc.1203594. Oncogene. 2000. PMID: 10851052 Review.
Cited by
-
Immunomodulatory cytokines as therapeutic agents for melanoma.Immunotherapy. 2011 May;3(5):673-90. doi: 10.2217/imt.11.45. Immunotherapy. 2011. PMID: 21554095 Free PMC article. Review.
-
IL-2 and IFN-gamma in the retina of diabetic rats.Graefes Arch Clin Exp Ophthalmol. 2010 Jul;248(7):985-90. doi: 10.1007/s00417-009-1289-x. Epub 2010 Mar 6. Graefes Arch Clin Exp Ophthalmol. 2010. PMID: 20213480
-
Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor.Mol Cell Biol. 2003 Jul;23(13):4532-41. doi: 10.1128/MCB.23.13.4532-4541.2003. Mol Cell Biol. 2003. PMID: 12808095 Free PMC article.
-
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.J Exp Med. 2000 Feb 7;191(3):529-40. doi: 10.1084/jem.191.3.529. J Exp Med. 2000. PMID: 10662798 Free PMC article.
-
Activation of extracellular signaling regulated kinase in natural killer cells and monocytes following IL-2 stimulation in vitro and in patients undergoing IL-2 immunotherapy: analysis via dual parameter flow-cytometric assay.Cancer Immunol Immunother. 2008 Aug;57(8):1137-49. doi: 10.1007/s00262-007-0444-7. Epub 2008 Jan 10. Cancer Immunol Immunother. 2008. PMID: 18193422 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources