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. 1998 Sep;42(9):2427-30.
doi: 10.1128/AAC.42.9.2427.

Influence of human serum on pharmacodynamic properties of an investigational glycopeptide, LY333328, and comparator agents against Staphylococcus aureus

G G Zhanel  1 , I D Kirkpatrick, D J Hoban, A M Kabani, J A Karlowsky
Affiliations

Influence of human serum on pharmacodynamic properties of an investigational glycopeptide, LY333328, and comparator agents against Staphylococcus aureus

G G Zhanel et al. Antimicrob Agents Chemother. 1998 Sep.

Abstract

The MICs and MBCs of 15 antibiotics for two strains of Staphylococcus aureus were determined in Mueller-Hinton broth (MHB) and 90% serum-10% MHB. Subsequent experiments established that highly protein-bound antibiotics (>/=80%), such as LY333328, demonstrated higher MICs and MBCs, less killing over an 8-h interval, and shorter postantibiotic effects in 90% serum-10% MHB than in MHB alone. Albumin was demonstrated to be almost solely responsible for changes in the aforementioned pharmacodynamic parameters of LY333328.

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Figures

FIG. 1
FIG. 1
Representative time-kill curve of ATCC 29213 S. aureus exposed to LY333328 at a concentration equal to the MIC in MHB (0.5 μg/ml). Symbols: ■, MHB control; ▴, MHB plus LY333328; •, MHBA control; ⧫, MHBA plus LY333328; ★, MHBS control; ✚, MHBS plus LY333328.
See this image and copyright information in PMC

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