Review
doi: 10.1016/s0959-440x(98)80119-x.
Four cholesterol-sensing proteins
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- PMID: 9729733
- DOI: 10.1016/s0959-440x(98)80119-x
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Review
Four cholesterol-sensing proteins
Curr Opin Struct Biol.
1998 Aug.
Abstract
What is the connection among the following three medical conditions: Niemann-Pick type C disease (a cause of mental retardation and early death), systemic lipidosis (in which an obscure side effect of numerous drugs transforms lysosomes into lamellar bodies), and holoprosencephaly (a catastrophe in embryonic development)? Recent evidence suggests that the pathogenesis in each use involves impaired sensing of cellular cholesterol.
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