Review
doi: 10.1126/science.281.5381.1305.
Death receptors: signaling and modulation
Affiliations
- PMID: 9721089
- DOI: 10.1126/science.281.5381.1305
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Review
Death receptors: signaling and modulation
Science.
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Abstract
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.
Comment in
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Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure.J Hepatol. 2003 Nov;39(5):883-5. doi: 10.1016/s0168-8278(03)00429-x. J Hepatol. 2003. PMID: 14568278 No abstract available.
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