Review
doi: 10.1016/s0960-9822(07)00336-3.
Adaptive thermogenesis: turning on the heat
Affiliations
- PMID: 9705924
- DOI: 10.1016/s0960-9822(07)00336-3
Item in Clipboard
Review
Adaptive thermogenesis: turning on the heat
Curr Biol.
.
Free article
Abstract
Brown adipocytes play important roles in the regulation of fat storage and body temperature, by virtue of their ability to uncouple mitochondrial fuel oxidation and ATP synthesis. The discovery of a tissue-specific transcriptional coactivator provides new insights into the regulation of thermogenesis by brown adipocytes.
Similar articles
-
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.Mol Cell Biol. 2004 Apr;24(7):3057-67. doi: 10.1128/MCB.24.7.3057-3067.2004. Mol Cell Biol. 2004. PMID: 15024092 Free PMC article.
-
Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.J Biol Chem. 2001 Jan 12;276(2):1486-93. doi: 10.1074/jbc.M006246200. J Biol Chem. 2001. PMID: 11050084
-
[Brown adipose tissue: physiologic effector of thermogenesis].Journ Annu Diabetol Hotel Dieu. 1990:27-31. Journ Annu Diabetol Hotel Dieu. 1990. PMID: 2195211 Review. French. No abstract available.
-
Adaptive thermogenesis: orchestrating mitochondrial biogenesis.Curr Biol. 1999 Oct 21;9(20):R767-9. doi: 10.1016/S0960-9822(00)80008-1. Curr Biol. 1999. PMID: 10531019 Review.
-
UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.Biochim Biophys Acta. 2001 Mar 1;1504(1):82-106. doi: 10.1016/s0005-2728(00)00247-4. Biochim Biophys Acta. 2001. PMID: 11239487 Review.
Cited by
-
Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.Biochemistry. 2012 Sep 4;51(35):6990-9. doi: 10.1021/bi3008824. Epub 2012 Aug 23. Biochemistry. 2012. PMID: 22897136 Free PMC article.
-
Genetic contributors to obesity.Can J Cardiol. 2007 Aug;23 Suppl A(Suppl A):23A-27A. doi: 10.1016/s0828-282x(07)71002-4. Can J Cardiol. 2007. PMID: 17668084 Free PMC article. Review.
-
Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain.J Comp Physiol B. 2007 Oct;177(7):743-52. doi: 10.1007/s00360-007-0171-6. Epub 2007 Jun 19. J Comp Physiol B. 2007. PMID: 17576568
-
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2366-71. doi: 10.1073/pnas.0610416104. Epub 2007 Feb 5. Proc Natl Acad Sci U S A. 2007. PMID: 17283342 Free PMC article.
-
Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans.Am J Hum Genet. 2004 Feb;74(2):272-82. doi: 10.1086/381717. Epub 2004 Jan 20. Am J Hum Genet. 2004. PMID: 14740316 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
