Review
doi: 10.1016/s0962-8924(98)01267-7.
The unfolded protein response: an intracellular signalling pathway with many surprising features
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- PMID: 9695849
- DOI: 10.1016/s0962-8924(98)01267-7
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Review
The unfolded protein response: an intracellular signalling pathway with many surprising features
Trends Cell Biol.
1998 Jun.
Abstract
The unfolded protein response (UPR) is an intracellular signalling pathway--originating in the endoplasmic reticulum (ER) and leading to the cell nucleus--that controls transcription of genes encoding ER-resident proteins. Recent developments in this field show that this pathway utilizes unique regulatory mechanisms, including translational attenuation and a regulated mRNA splicing step catalysed by a bifunctional transmembrane kinase/endoribonuclease and tRNA ligase. This review describes the characterization of the UPR signalling pathway, focusing on the novel regulatory mechanisms that it has revealed.
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