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Case Reports
. 1998;45(2):81-2.

Endothelin-1 and 5-fluorouracil-induced cardiotoxicity

C Porta  1 , M Moroni, S Ferrari, G Nastasi
Affiliations
  • PMID: 9687887
Case Reports

Endothelin-1 and 5-fluorouracil-induced cardiotoxicity

C Porta et al. Neoplasma. 1998.

Abstract

Cardiotoxicity is an uncommon side-effect of 5-FU-based chemotherapy. Coronary artery vasospasms have been postulated to be involved in the pathogenesis of this rare but serious problem. We found high plasma levels of ET-1, a potent natural vasoconstrictor, in two patients who experienced two of the commonest clinical manifestations of 5-FU-induced cardiac toxicity--i.e., angina pectoris and chronic heart failure. We, therefore, propose ET-1 as the ultimate mediator of this toxicity, even though the mechanism of ET-1 increase in peripheral venous blood is still unknown. Finally, another important question still remains unresolved: is the release of ET-1 from normal coronary endothelial cells the prime cause or simply the consequence of 5-FU-related cardiotoxicity?

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