doi: 10.1073/pnas.95.12.6573.
Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors
Affiliations
- PMID: 9618452
- PMCID: PMC33861
- DOI: 10.1073/pnas.95.12.6573
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Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Structure of the hematopoietic compartment. Bone
marrow pluripotent stem cells may either self-renew or give rise to
eight different hematopoietic lineages through a gradual process of
commitment and differentiation. Some of the cytokines involoved in
supporting this process are illustrated. M-CSF, Macrophage colony
stimulating factor; SCF, stem cell factor; Epo, erythropoietin; Tpo,
thrombopoietin; CFU-GEMM, CFU
granulocyte-erythroid-monocyte-megakaryocyte; CFU-GM, CFU
granulocyte-monocyte; CFU-me, CFU megakaryocyte; CFU-E, CFU erythroid;
CFU-Eo, CFU eosinophil; BFU-E, burst-forming unit erythroid.
The stochastic model for cell fate determination.
A possible sequence of events or “family tree” in which a single
progenitor gives rise to a hematopoietic colony containing a mixture of
differentiated and undifferentiated cells. “Birth” (self-renewal,
black circles) or “death” (differentiation, white circles) occur
as probabilistic events (11). The probability P or
“1-P” for each outcome is the same at each
generation.
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