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. 1998 May 4;187(9):1367-71.
doi: 10.1084/jem.187.9.1367.

A new look at T cells

A J McMichael  1 , C A O'Callaghan
Affiliations

A new look at T cells

A J McMichael et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Model of HLA B8–peptide tetramer. Top, the complex without the fluorochrome, bottom, phycoerythrin bound to the streptavidin. Light blue, streptavidin; dark blue, B8 heavy chain; intermediate blue, beta-2 microglobulin; purple, the peptide; red, phycoerythrin. The phycoerythrin is represented by the crystallographically determined structure, but in its biologically active form can exist as an even larger trimer of this structure. The potential extended length between the biotin molecule and the α3 domain is 30Å.
Figure 2
Figure 2
(A) Scheme of the life history of CTL clones specific for a single epitope. nCTLs are rapidly triggered by primary virus infection to generate very large numbers of effector eCTLs that are functional but doomed to die by apoptosis. A small subpopulation takes an alternative route and maintains their growth potential; these pCTLs are detectable by LDA and carry long-term memory. (B) Alternative scheme for the life history of CTLs. On contact with antigen, CTLs proliferate at different rates. At the extremes, greatly expanded eCTLs apoptose and those that proliferated very little persist as long-term memory cells. Many cells fall in between. This model predicts that the clonal composition of eCTLs and pCTLs would be different. A theoretical problem with this model is that cells that divide poorly in the primary response have the greatest growth potential and have to give rise to rapidly dividing daughter cells on reinfection.
Figure 2
Figure 2
(A) Scheme of the life history of CTL clones specific for a single epitope. nCTLs are rapidly triggered by primary virus infection to generate very large numbers of effector eCTLs that are functional but doomed to die by apoptosis. A small subpopulation takes an alternative route and maintains their growth potential; these pCTLs are detectable by LDA and carry long-term memory. (B) Alternative scheme for the life history of CTLs. On contact with antigen, CTLs proliferate at different rates. At the extremes, greatly expanded eCTLs apoptose and those that proliferated very little persist as long-term memory cells. Many cells fall in between. This model predicts that the clonal composition of eCTLs and pCTLs would be different. A theoretical problem with this model is that cells that divide poorly in the primary response have the greatest growth potential and have to give rise to rapidly dividing daughter cells on reinfection.
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