Monitoring randomised controlled trials. Parkinson's disease trial illustrates the dangers of stopping early
- PMID: 9552993
- PMCID: PMC1112981
- DOI: 10.1136/bmj.316.7139.1183
Monitoring randomised controlled trials. Parkinson's disease trial illustrates the dangers of stopping early
Comment on
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Investigation by Parkinson's Disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: further results of randomised trial and confidential inquiry.BMJ. 1998 Apr 18;316(7139):1191-6. doi: 10.1136/bmj.316.7139.1191. BMJ. 1998. PMID: 9583926 Free PMC article. Clinical Trial.
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References
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- Ben-Shlomo Y, Churchyard A, Head J, Hurwitz B, Overstall P, Ockelford J, et al. Investigation by Parkinson’s Disease Research Group of the United Kingdom into excess mortality seen with combined levodopa and selegiline in patients with early, mild Parkinson’s disease. BMJ. 1998;316:1191–1196. - PMC - PubMed
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- Birkmayer W, Knoll J, Riederer P, Youdim MBH, Hars V, Marton J. Increased life expectancy resulting from addition of l-deprenyl to Madopar treatment in Parkinson’s disease: a long term study. J Neural Transm. 1985;64:113–127. - PubMed
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- Freedman LS, Spiegelhalter DJ. The assessment of subjective opinion and its use in relation to stopping rules for clinical trials. Statistician. 1983;32:153–160.
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