Review
doi: 10.1016/s0969-2126(98)00027-6.
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2
Affiliations
- PMID: 9551546
- DOI: 10.1016/s0969-2126(98)00027-6
Item in Clipboard
Review
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2
Structure.
.
Free article
Abstract
The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains. Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.
Similar articles
-
Crystal structure of the tyrosine phosphatase SHP-2.Cell. 1998 Feb 20;92(4):441-50. doi: 10.1016/s0092-8674(00)80938-1. Cell. 1998. PMID: 9491886
-
Molecular dynamics simulations on the free and complexed N-terminal SH2 domain of SHP-2.In Silico Biol. 2002;2(3):305-11. In Silico Biol. 2002. PMID: 12542415
-
Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1141-5. doi: 10.1073/pnas.93.3.1141. Proc Natl Acad Sci U S A. 1996. PMID: 8577729 Free PMC article.
-
Shp-2 tyrosine phosphatase: signaling one cell or many.Exp Cell Res. 1999 Nov 25;253(1):47-54. doi: 10.1006/excr.1999.4668. Exp Cell Res. 1999. PMID: 10579910 Review.
-
Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.Curr Opin Immunol. 2000 Jun;12(3):307-15. doi: 10.1016/s0952-7915(00)00092-3. Curr Opin Immunol. 2000. PMID: 10781410 Review.
Cited by
-
Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies.Mol Cancer Ther. 2013 Sep;12(9):1738-48. doi: 10.1158/1535-7163.MCT-13-0049-T. Epub 2013 Jul 3. Mol Cancer Ther. 2013. PMID: 23825065 Free PMC article.
-
A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.J Biol Chem. 2021 Jan-Jun;296:100538. doi: 10.1016/j.jbc.2021.100538. Epub 2021 Mar 12. J Biol Chem. 2021. PMID: 33722610 Free PMC article.
-
SHP-2 expression negatively regulates NK cell function.J Immunol. 2009 Dec 1;183(11):7234-43. doi: 10.4049/jimmunol.0900088. Epub 2009 Nov 13. J Immunol. 2009. PMID: 19915046 Free PMC article.
-
Measuring Protein Tyrosine Phosphatase Activity Dependent on SH2 Domain-Mediated Regulation.Methods Mol Biol. 2023;2705:351-358. doi: 10.1007/978-1-0716-3393-9_18. Methods Mol Biol. 2023. PMID: 37668983
-
Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.J Signal Transduct. 2011;2011:195239. doi: 10.1155/2011/195239. Epub 2011 Jun 7. J Signal Transduct. 2011. PMID: 21799948 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
