Review
How do G-proteins stay at the plasma membrane?
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- PMID: 9493010
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Review
How do G-proteins stay at the plasma membrane?
Essays Biochem.
1997.
Abstract
G-protein alpha-subunits are modified by combinations of fatty acyl groups. G-protein gamma-subunits are isoprenylated. These modifications play central roles in membrane association of the G-proteins. Attachment of long-chain fatty acyl chains to G-protein alpha-subunits via a thioester linkage allows the possibility of dynamic regulation of membrane attachment and function.
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